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Medical Treatment of Benign Prostatic Hyperplasia

Porena Massimo

Minerva Medica 2016

Pagg. 112

Isbn: 9788877118738


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Minerva Medica 2016


The medical therapy for benign prostatic hyperplasia has a short history, which started no farther back than 25-30 years ago. Before then, surgery was the only real treatment for prostatic disease aimed at also resolving the associated lower urinary tract symptoms (LUTS).
Nowadays, several drugs are available for the treatment of prostatic enlargement, which stop or minimize glandular growth, improve bladder neck and urethral hypertonicity or reduce the associated LUTS. They can be used as a monotherapy or in various combinations.
This book is meant to be a summary of the latest developments in the management of benign prostatic hyperplasia and a guide to the use of drugs, focusing on their biological mechanisms of action and their adverse events. The Authors involved in this work are the back-bone of research in this field in Italy. Therefore this is an indispensable reference book useful to fellows and specialists in urology.
Contents
ETIOPATHOGENETIC AND PATHOPHYSIOLOGIC PATHWAYS
 
Ethiopathogenesis
Pathophysiology of benign prostatic obstruction 
Bladder and prostatic urethra innervation 
CLINICAL ENDPOINTS OF MEDICAL TREATMENT, INDICATIONS AND PATIENT SELECTION 
Indications and patient selection 
Clinical endpoints 
MEDICAL TREATMENT 
α1-blockers
 
α1-blockers 
Androgen manipulation: 5-α-reductase inhibitors, other antiandrogens, aromatase inhibitors (antiestrogens) 
5-α-reductase inhibitors 
Other androgen manipulations 
Treatment of symptoms related to BPH: anticholinergics (antimuscarinics), phosphodiesterase-5 inhibitors, β3-agonists 
Muscarinic receptor antagonists 
Phosphodiesterase type 5 inhibitors 
Combination therapy in BPH 
Therapy with α-adrenergic blockers 
Androgen manipulation 
Combination therapy with α blocker and 5-α-reductase inhibitor 
Anticholinergic (antimuscarinic) receptor blockers 
Phosphodiesterase inhibitors 
Phytotherapy and nutraceuticals 
Pygeum africanum 
Hypoxis hemerocallidea 
Cucurbita pepo 
Epilobium spp. 
Lycopersicum esculentum 
Pinus pinaster 
Roystonea regia 
Secale cereale 
Urtica dioica 
Serenoa repens 
Conclusions

 

  • Anno 2016
  • Autore Porena Massimo
  • codice isbn 9788877118738
  • Edizione In lingua inglese.
  • Nota Copertina flessibile
  • Pagine 112

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