OSTEO-ONCOLOGY TEXTBOOK
Amadori, Cascinu, Conte, Ibrahim,
Poletto 2010,
586 pagg.
Amadori, Cascinu, Conte, Ibrahim,
Poletto 2010,
586 pagg.
Nel 2000, è iniziato un processo educativo che ha portato a una rivoluzione culturale, educativa e sanitaria nel campo della malattia ossea neoplastica e alla creazione di una nuova disciplina, l’osteoncologia, così chiamata perché si concentra sui tumori ossei primari e metastatici e anche sulla salute delle ossa durante il trattamento antitumorale. Gli obbiettivi principali del progetto di osteoncologia sono quelli di promuovere la creazione di centri multidisciplinari di osteoncologia per diagnosi, terapia e riabilitazione della malattia ossea legata al cancro e anche per svolgere attività di ricerca in questo settore. Programmi di istruzione multidisciplinari teorico-pratici, compresi quelli a livello universitario, sono stati organizzati sia in Italia sia all'estero per la formazione di medici (osteoncologi) e di altri operatori sanitari in questa nuova disciplina. Sebbene le informazioni sulla malattia ossea neoplastica abbondino in letteratura, queste tendono a limitarsi ad articoli che si occupano di determinate malattie e discipline specifiche. È stato così deciso di mettere tutte queste informazioni in un testo, al fine di fornire una guida completa di riferimento (cura, ricerca, formazione) per medici osteoncologi. Il volume dà descrizioni dettagliate di anatomia, fisiologia e biologia dell'osso, per proseguire con fisiopatologia, epidemiologia, caratteristiche cliniche, diagnosi e terapia dei tumori ossei primari sia delle metastasi ossee; queste ultime rappresentano la principale causa di morbilità nei pazienti oncologici. Un altro capitolo è dedicato al danno osseo causato da trattamenti antitumorali, concentrandosi su patogenesi, diagnosi e terapia. Una sezione del libro si occupa di ricerca epidemiologica, preclinica e clinica in osteoncologia e il capitolo conclusivo esamina il tema importante della gestione multidisciplinare dei pazienti con malattia ossea correlata al cancro.
Indice
OVERVIEW
Functional anatomy of bone
Gastone Marotti
Introduction
Histogenesis
Macroscopic features
Microscopic structure
Bone cell functional relationships and signaling
Conclusions
References
Physiology of the bone
Alberto Angeli, Andrea Dovio
Introduction
Bone structure and function
Bone turnover - The remodeling cycle
Bone turnover - Biochemical markers
Bone turnover - Histomorphometry
Regulation of osteoclast number and activity
Regulation of osteoblast number and activity
Osteoimmunology
Hematopoietic stem cell niche and cross-talk between bone cells and stem cells
Bone as the calcium reserve
An overview of osteoporosis
Conclusions
References
Physiopathology of bone metastases
Francesco Bertoldo, Emanuela Flamini, Daniele Santini, Toni Ibrahim
Introduction
Bone metastasis beginning and development
Origin of evident osteolytic lesion
Pathogenesis of osteoblastic lesions
References
SPECIFIC ISSUES
Primitive bone tumors
Roberto Casadei, Mario Mercuri
Introduction
Epidemiology
Imaging diagnosis
Biopsy and anatomopathological diagnosis
Clinical manifestations
Staging
Treatments
Conclusions
References
BONE METASTASES
Natural history and epidemiology
Rossana Berardi, Chiara Pierantoni, Mario Scartozzi, Stefano Cascinu
Introduction
Bone metastases
Conclusions
References
Imaging diagnosis
Lorenzo Faggioni, Davide Caramella, Carlo Bartolozzi
Introduction
Conventional X-ray
Computed tomography
Magnetic resonance imaging
Conclusions
References
Anatomopathological diagnosis
Franco Bertoni, Patrizia Bacchini, Krishnan Unni
Introduction
Cytological diagnosis: medullary aspirate and bone aspirate
Histological diagnosis: bone marrow and bone biopsy
Biomolecular characterization
Problems in diagnosis and conclusions
References
Clinical manifestation
Toni Ibrahim, Laura Mercatali, Roberto Casadei, Roberto Sabbatini
Introduction
Pain
Pathological fractures
Spinal cord compression
Hypercalcemia
Medullary suppression
Systemic effects
Conclusions
References
Pain and bone metastases
Oscar Corli, Marco Maltoni
Introduction and epidemiological aspects
Pathophysiology of metastatic bone pain
Pharmacotherapy for cancer pain
Nonpharmacological treatments
Breakthrough pain or episodic pain
Conclusions
References
Pharmacological treatment
Valentina Guarneri, Federica Bertolini, Stefano Cascinu, Toni Ibrahim
Introduction
Specific antitumor treatment
Specific bone metastases treatment
Medical treatment of spinal cord compression
Medical treatment of hypercalcemia
Medical treatment of medullar suppression
Conclusions
References
Radiotherapy of bone metastases
Filippo Bertoni, Paolo Antognoni
Introduction
Radical treatment
Palliative treatment and prevention of bone complications
Conclusions
References
Nuclear medicine
Giovanni Paganelli, Concetta De Cicco
Introduction
Diagnostic imaging
Radiometabolic treatment
Conclusions
References
Interventional radiology
Filippo Calzolari, Valeria Allegra Pupillo, Enrico Petrella
Introduction
CT-guided biopsy
Cementoplasty
Percutaneous vertebroplasty
Kyphoplasty
Embolization
Radiofrequency thermoablation
Other procedures
Locoregional therapy
Conclusions
References
Surgical treatment
Roberto Casadei
Introduction
Vertebral column
Pelvis
Limbs
Conclusions
References
Rehabilitation treatment
Maria Rosa Strada, Raffaella Palumbo, Giovanni Bernardo
Introduction
Rehabilitation of patients with vertebral column disease
Rehabilitation of patients with upper extremity disease
Rehabilitation of patients with hip and lower extremity disease
Conclusions
References
Bone metastases of unknown origin
Roberto Sabbatini, Stefano Cascinu, Alessia Ferrari, Toni Ibrahim
Introduction
Epidemiology
Diagnosis
Therapy
Conclusions
References
BONE HEALTH IN OSTEO-ONCOLOGY
Cancer treatment-induced bone loss
Antonio Frassoldati
Introduction
Endocrine therapies and bone loss in breast cancer
Endocrine therapies and bone loss in prostate cancer
Management of cancer treatment-induced bone loss
Conclusions
References
RESEARCH AND PATIENT MANAGEMENT IN OSTEO-ONCOLOGY
Research in osteo-oncology
Epidemiology
Lauro Bucchi, Toni Ibrahim
Introduction
Descriptive epidemiology
Analytical epidemiology
Incidence of metachronous metastases
Population-based clinical epidemiology
Hospital-based clinical epidemiology
Epidemiology of cancer pain
Metastatic cancer outcomes research
Economics of metastatic cancer
Health services research
Biological studies
Emanuela Scarpi, Emanuela Flamini
Diagnostic studies
Introduction
Study designs for diagnostic tests
Study design of target oriented diagnostic tests
ROC curve and area under the curve
Critical evaluation of the evidence about diagnostic tests
Preclinical pharmacology
Introduction and overview
Regulatory requirements
Preclinical drug development
Pharmacology
Toxicology/drug safety
Drug formulation development
Research of prognostic and predictive factors
Biological studies in osteo-oncology
From bone reabsorption markers to therapeutic targets in bone metastasis
From preclinical studies to clinical trials
Endothelin-1
Cathepsin K
Phases of clinical trials
Oriana Nanni, Patrizia Serra
Introduction
Phase I
Phase II
Phase III
Phase IV
Methodology of clinical research in patients with bone metastases
Pain assessment
Quality of life assessment
Bone pain and quality of life in bone oncology
Conclusions
References
Multidisciplinary organization models in osteo-oncology
Toni Ibrahim, Laura Mercatali, Emanuele Sacanna, Nicola Calipari
Introduction
Management of primary bone cancers
Management of bone metastases
Conclusions
References
Glossary
Index
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